Impact of objectively measured sedentary behaviour on changes in insulin resistance and secretion over three years: interaction with weight gain. The RISC Study

a INSERM CESP Centre for Research in Epidemiology and Population Health, U1018, Epidemiology of diabetes, obesity and chronic kidney disease over the life course, Villejuif, France b University Paris 11, UMRS 1018, Villejuif, France c EMGO Institute for Health Care Research, Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands d Diabetes Research Centre, Department of Endocrinology, Odense University Hospital, Odense, Denmark e Institute of Clinical Research, University of Southern Denmark, Odense, Denmark f CRNH Rhone–Alpes, Lyon University, INSERM U1060, CarMeN laboratory CENS, g Univ Lyon-1, Hospices Civils de Lyon, Service d’Endocrinologie, Diabétologie-Nutrition, F-69621 Lyon, France h Steno Diabetes Center, Gentofte, Denmark I Metabolic Research Unit, St James’s Hospital, Trinity College, Dublin 8, Ireland j Institute of Cardiometabolic Disease and Nutrition (ICAN), University Pierre et Marie Curie-Paris 6, Paris, France k Department of Nutrition, Pitié-Salpetrière Hospital (AP-HP), CRNH IdF, Paris, France l Nutritional Epidemiology Unit, UMR INSERM U557/INRA U1125/CNAM/University Paris 13, CRNH IdF, Bobigny, France The RISC Study group see Supplementary Material